Structural and functional basis of chromatin remodelling
Structural and functional basis of chromatin remodelling
In eukaryotes, DNA is made to fit inside the cell nucleus through a high degree of compaction that is enabled by assembly into chromatin.
Processes such as DNA damage repair and transcription require localized changes in chromatin compaction. Cells have multiple molecular strategies to control this. In one, multi-protein chromatin remodelling complexes use the energy from ATP hydrolysis to alter DNA compaction. Among them, the mSWI/SNF complex is of special interest because several subunits, including components of yet unknown function are coded by genes mutated or mis-expressed in many forms of cancer.
The impact of these cancer-associated mutations on mSWI/SNF assembly and function, and on the cancerous phenotype, is mostly unknown.
By combining cryo-electron microscopy, x-ray crystallography, molecular biology and biochemistry we will gain understanding of this complex at the molecular and atomic level. Our expectation is that such information will contribute to the development of future therapeutic agents against cancer and other human diseases.
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Congratulations to Franck MARTIN on the acceptance of his thesis!
His work, supervised by Elisa BERGAMIN, is titled: Structural and Functional Studies of the Chromatin Remodeling Complex Mammalian SWI/SNF. …
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Publications
2025
Pre-publication, Working Document
A nuclear trafficking checkpoint licenses resolution of RNA–DNA hybrids at stalled RNAPII to maintain genome stability under genotoxic stress
- Jérémy Sandoz
- Clara Capelli
- Philippe Catez
- Anthony Hannus
- Alice Brion
- Lise-Marie Donnio
- Pierre-Olivier Mari
- Jean-Paul Concordet
- Elisa Bergamin
- Emmanuel Compe
- Jean-Marc Egly
- Frédéric Coin
Pre-publication, Working Document
Stress-Induced Nuclear Import Governs Transcription Recovery after DNA Damage
- Frédéric Coin
- Jérémy Sandoz
- Philippe Catez
- Anthony Hannus
- Alice Brion
- Lise-Marie Donnio
- Pierre-Olivier Mari
- Jean Paul Concordet
- Elisa Bergamin
Article in a journal
Structure of the nucleosome-bound human BCL7A
- Franck Martin
- Asgar Abbas Kazrani
- Julie Lafouge
- Dana Mariel Diaz Jimenez
- Stéphanie Siebert
- Leonie Fabbro-Burtschell
- Emma Maillard
- Karine Lapouge
- Haydyn David Thomas Mertens
- Claude Sauter
- Alexander Leitner
- Francoise Ochsenbein
- Alexandre Blais
- Elisa Bergamin
Nucleic Acids Research ; Volume: 53