Chemical biophysics of transcriptional signaling
Team Leader : Annick DEJAEGERE
Department : Integrated structural biology
Nuclear receptors are ligand-regulated transcription factors that control nearly all aspects of human physiology. We are studying several members of the nuclear receptor family including the vitamin D receptor (VDR), peroxisome-activated receptors (PPARs) and retinoid receptors (RARs and RXRs). The objective of our research is to understand how the activation and repression of nuclear receptor transcription are regulated at the structural and molecular level using X-ray crystallography and other structural, biophysical and cellular methods.
Team Leader : Annick DEJAEGERE
Department : Integrated structural biology
Biophysical Chemistry ; Volume: 210 ; Page: 2-8
Chemical Science ; Volume: 7 ; Page: 1033-1037
Vitamins and hormones ; Volume: 100 ; Page: 83-116
PLoS Genetics ; Volume: 11 ; Page: e1005213
Journal of Molecular Biology
PLoS Computational Biology ; Volume: 9 ; Page: e1003012
Analytical Biochemistry ; Volume: 426 ; Page: 106-108
Journal of Biological Chemistry ; Page: epub ahead of print
PLoS ONE ; Volume: 5 ; Page: e15119
Journal of Steroid Biochemistry and Molecular Biology ; Volume: 121 ; Page: 84-87