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Structure-function relationships of nuclear receptors and their co-regulators

Structure-function relationships of nuclear receptors and their co-regulators

SUBGROUP LEADER

Natacha ROCHEL-GUIBERTEAU

Nuclear receptors are ligand-regulated transcription factors that control nearly all aspects of human physiology. We are studying several members of the nuclear receptor family including the vitamin D receptor (VDR), the peroxisome-activated receptors (PPARs) and the retinoid receptors (RARs and RXRs). A major interest of the group is to understand how the activation and repression of nuclear receptor transcription are regulated at the structural and molecular level using experimental methods combining structural, biophysical and cellular approaches. Our work concerns ligand recognition, allosteric control of nuclear receptor activity and coregulators recognition in a physiological and pathological context. In addition, we characterize important coregulators involved in the control of transcription (Mediator, CBP/p300) and their dysfunction in a pathological context. These studies provide important information to propose new therapeutic strategies and to design new therapeutic agents with selective activities.

Link to full Publication list: orcid.org/0000-0002-3573-5889
 

 

Collaborations and networks

•    Isabelle Bernard-Pierrot and François Radvanyi (Institut Curie, Paris, France)
•    Gilles Guichard and Morgane Pasco (IECB, Bordeaux, France)
•    Sarah Cianférani (IPHC, Strasbourg, France)
•    Célia Deville and Bruno Kieffer (IGBMC, France)
•    Wojciech Krezel (IGBMC, France)
•    Nicolas Le May (Laboratoire de génétique médicale, Strasbourg, France)
•    Gilles Laverny and Daniel Metzger (IGBMC, France)
•    Antonio Mourino (University Santiago de Compostella, Spain)
•    Vladimir Torbeev (ESBS, Strasbourg, France)

Awards and recognitions

Natacha Rochel
2012 FRM Prize 

Anna Belorusova  
2016 3rd "Biophysics in drug discovery" NovAliX conference - best poster presentation 
2016 PhD Thesis Prize by the University of Strasbourg Foundation 
2016 PhD Thesis Prize by the Biological Society of Strasbourg
 

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