Chemical biophysics of transcriptional signaling
Team Leader : Annick DEJAEGERE
Department : Integrated structural biology
SUBGROUP LEADER
Nuclear receptors are ligand-regulated transcription factors that control nearly all aspects of human physiology. We are studying several members of the nuclear receptor family including the vitamin D receptor (VDR), peroxisome-activated receptors (PPARs) and retinoid receptors (RARs and RXRs). The objective of our research is to understand how the activation and repression of nuclear receptor transcription are regulated at the structural and molecular level using X-ray crystallography and other structural, biophysical and cellular methods.
Team Leader : Annick DEJAEGERE
Department : Integrated structural biology
Molecular Pharmacology ; Volume: 67 ; Page: 1566-73
Acta Crystallographica Section D: Biological Crystallography ; Volume: 60 ; Page: 2048-2050
EMBO Reports ; Volume: 5 ; Page: 877-882
Journal of Steroid Biochemistry and Molecular Biology ; Volume: 89-90 ; Page: 55-59
Journal of Medicinal Chemistry ; Volume: 47 ; Page: 1956-1961
EMBO Reports ; Volume: 5 ; Page: 423-429
Nature ; Volume: 426 ; Page: 91-96
Journal of Molecular Biology ; Volume: 307 ; Page: 557-576
Journal of Biological Chemistry ; Volume: 276 ; Page: 7465-7474
Biochemical Journal ; Volume: 344 ; Page: 297-303
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