Regulation of DNA topology
Team Leader : Valerie LAMOUR
Department : Integrated structural biology
Structure function of complexes involved in the HIV replication cycle, drug design
Structure function of complexes involved in the HIV replication cycle, drug design
SUBGROUP LEADER
Teams
Members
Publications
2019
Article in a journal
Human H4 tail stimulates HIV-1 integration through binding to the carboxy-terminal domain of integrase
- Eric Mauro
- Paul Lesbats
- Delphine Lapaillerie
- Stéphane Chaignepain
- Benoit Maillot
- Oyindamola Oladosu
- Xavier Robert
- Francesca Fiorini
- Bruno Kieffer
- Serge Bouaziz
- Patrice Gouet
- Marc Ruff
- Vincent Parissi
Nucleic Acids Research ; Volume: 47 ; Page: 3607-3618
Article in a journal
Structural Basis for E. coli Penicillin Binding Protein (PBP) 2 Inhibition, a Platform for Drug Design
- Nicolas Lévy
- Jean-Michel Bruneau
- Erwann Le Rouzic
- Damien Bonnard
- Frédéric Le Strat
- Audrey Caravano
- Francis Chevreuil
- Julien Barbion
- Sophie Chasset
- Benoit Ledoussal
- François Moreau
- Marc Ruff
Journal of Medicinal Chemistry ; Volume: 62 ; Page: 4742-4754
Article in a journal
Structures and Functions of the HIV-1 Pre-Integration Complexes
- Julien Batisse
- Eduardo Bruch
- Nicolas Levy
- Patrice Gouet
- Stéphane Emiliani
- Vincent Parissi
- Marc Ruff
Biophysical Journal ; Volume: 116 ; Page: 62a
2018
Article in a journal
Post-translational modifications in DNA topoisomerase 2α highlight the role of a eukaryote-specific residue in the ATPase domain
- Claire Bedez
- Christophe Lotz
- Claire Batisse
- Arnaud Vanden Broeck
- Roland Stote
- Eduardo Howard
- Karine Pradeau Aubreton
- Marc Ruff
- Valerie Lamour
Scientific Reports ; Volume: 8
Article in a journal
Genetic Flexibility of the NKNK Motif in HIV-1 Integrases Allows Its Involvement in Multiple Functions During Infection
- Marine Kanja
- Pierre Cappy
- Guillermo Blanco-Rodriguez
- Nicolas Levy
- Sylvie Schmidt
- Romain Gasser
- Paola Rossolillo
- Christiane Moog
- M. Ruff
- Francesca Di Nunzio
- Matteo Negroni
- Daniela Lener
SSRN : Social Science Research Network
Article in a journal
Structure-function analyses unravel distinct effects of allosteric inhibitors of HIV-1 integrase on viral maturation and integration
- Damien Bonnard
- Erwann Le Rouzic
- Sylvia Eiler
- Céline Amadori
- Igor Orlov
- Jean-Michel Bruneau
- Julie Brias
- Julien Barbion
- Francis Chevreuil
- Daniele Spehner
- Sophie Chasset
- Benoit Ledoussal
- François Moreau
- Ali Saib
- Bruno P. Klaholz
- Stéphane Emiliani
- Marc Ruff
- Alessia Zamborlini
- Richard Benarous
Journal of Biological Chemistry ; Volume: 293 ; Page: 6172-6186
Chapter of the book
Unstable Protein Purification Through the Formation of Stable Complexes
- Sylvia Eiler
- Nicolas Lévy
- Benoit Maillot
- Julien Batisse
- Karine Pradeau Aubreton
- Oyindamola Oladosu
- Marc Ruff
Methods in Molecular Biology ; Page: 315-328
Article in a journal
Toward High Resolution Structures of the HIV-1 In/LEDGF/DNA Complex
- Julien Batisse
- Eduardo Bruch
- Nicolas Levy
- Benoit Maillot
- Sylvia Eiler
- Oyindamola Oladosu
- Marc Ruff
Biophysical Journal ; Volume: 114 ; Page: 218a
2017
Article in a journal
The HIV-1 integrase-LEDGF allosteric inhibitor MUT-A: resistance profile, impairment of virus maturation and infectivity but without influence on RNA packaging or virus immunoreactivity
- Céline Amadori
- Yme Ubeles van Der Velden
- Damien Bonnard
- Igor Orlov
- Nikki van Bel
- Erwann Le Rouzic
- Laia Miralles
- Julie Brias
- Francis Chevreuil
- Daniele Spehner
- Sophie Chasset
- Benoit Ledoussal
- Luzia Mayr
- François Moreau
- Felipe García
- José Gatell
- Alessia Zamborlini
- Stéphane Emiliani
- Marc Ruff
- Bruno P. Klaholz
- ...
Retrovirology ; Volume: 14 ; Page: 50
Article in a journal
Modulation of chromatin structure by the FACT histone chaperone complex regulates HIV-1 integration
- Julien Matysiak
- Paul Lesbats
- Eric Mauro
- Delphine Lapaillerie
- Jean-William Dupuy
- Angelica P. Lopez
- Mohamed Salah Benleulmi
- Christina Calmels
- Marie-Line Andreola
- Marc Ruff
- Manuel Llano
- Olivier Delelis
- Marc Lavigne
- Vincent Parissi
Retrovirology ; Volume: 14 ; Page: 39