Team Leader : Daniel METZGER
Department : Functional genomics and cancer
Estrogens and androgens stimulate the proliferation of epithelial cells of the breast and prostate, and contribute to the development of tumors. Breast and prostate cancers are the most common cancers in women and men, respectively, and are a major cause of death. Hormonal treatments based on anti-estrogens (e.g. Tamoxifen) and anti-androgens (e.g. flutamide, bicalutamide) are effective for some forms of these cancers, but also lead to resistance.
In order to study the molecular and cellular mechanisms underlying the initiation and progression of these cancers, we established mouse models reproducing the characteristics and kinetics of the human pathologies. This project aims to deconstruct the cellular complexity of their microenvironment, understand the molecular mechanisms of disease initiation and progression, as well as analyze the epigenetic signature and plasticity of tumor cells.
Science ; Volume: 355 ; Page: 748 - 752
AJP - Endocrinology and Metabolism ; Volume: 311 ; Page: E649-E660
Endocrine-Related Cancer ; Volume: 23 ; Page: 221--233
PLoS ONE ; Volume: 8 ; Page: e81175
Journal of Investigative Dermatology ; Volume: 131 ; Page: 2324-2327
Cell ; Volume: 145 ; Page: 224-241
Journal of Cell Science ; Volume: 122 ; Page: 2699-709
Molecular Biology of the Cell ; Volume: 20 ; Page: 3192-9
Journal of Investigative Dermatology ; Volume: 129 ; Page: 1459-70
Proceedings of the National Academy of Sciences of the United States of America ; Volume: 106 ; Page: 4278-83