3'-5' RNA decay and effects on pathologies

Presentation
Teams
Members
Publications

3'-5' RNA decay and effects on pathologies

SUBGROUP LEADER

While the main mRNA decay pathway involves the 5’ to 3’ degradation of the mRNA body, 3’ to 5’ exonucleolytic mRNA trimming has been shown to play a major role for the elimination of defective, poorly translatable transcripts. Factors involved in the latter pathway are altered in a rare human genetic disease, underlining its importance. In this context, we are testing the role of these factors in pathological conditions. Moreover, we have identified new factors associated with 3’-5’ mRNA decay and are actively pursuing their characterization.

Teams

Eukaryotic mRNA decay
Team Leader : Bertrand SERAPHIN
Department : Executive management

Members

Researchers

Publications

2017
- Architecture of the yeast elongator complex
  - M Dauden
  - J Kosinski
  - Olga Kolaj-Robin
  - A Desfosses
  - A Ori
  - C Faux
  - N Hoffmann
  - O Onuma
  - K Breunig
  - M Beck
  - C Sachse
  - Bertrand Séraphin
  - S Glatt
  - C Muller
  EMBO Reports ; Volume: 18 ; Page: 264-279
  HAL DOI
- Structures and activities of the Elongator complex and Its cofactors
  - Olga Kolaj-Robin
  - Bertrand Séraphin
  Enzymes ; Volume: 41 ; Page: 117-149
  HAL DOI
2016
- Structure of the active form of Dcp1–Dcp2 decapping enzyme bound to m7GDP and its Edc3 activator
  - Clément Charenton
  - Valerio Taverniti
  - Claudine Gaudon-Plesse
  - Régis Back
  - Bertrand Séraphin
  - Marc Graille
  Nature Structural and Molecular Biology ; Volume: 23 ; Page: 982-986
  HAL DOI
- Acetylation-Dependent Control of Global Poly(A) RNA Degradation by CBP/p300 and HDAC1/2
  - Sahil Sharma
  - Fabian Poetz
  - Marius Bruer
  - Thi Bach Nga Ly-Hartig
  - Johanna Schott
  - Bertrand Séraphin
  - Georg Stoecklin
  Molecular Cell ; Volume: 63 ; Page: 927-38
  HAL DOI
- Structural basis for tRNA modification by Elp3 from Dehalococcoides mccartyi
  - Sebastian Glatt
  - Rene Zabel
  - Olga Kolaj-Robin
  - Osita Onuma
  - Florence Baudin
  - Andrea Graziadei
  - Valério Taverniti
  - Yu-Ting Lin
  - Frauke Baymann
  - Bertrand Séraphin
  - Karin D Breunig
  - Christoph W Müller
  Nature Structural and Molecular Biology ; Page: 794-802
  HAL DOI
- BTG2 bridges PABPC1 RNA-binding domains and CAF1 deadenylase to control cell proliferation
  - Benjamin Stupfler
  - Catherine Birck
  - Bertrand Séraphin
  - Fabienne Mauxion
  Nature Communications ; Volume: 7
  HAL DOI
- Gbp2 interacts with THO/TREX through a novel type of RRM domain
  - Santiago Martínez-Lumbreras
  - Valério Taverniti
  - Silvia Zorrilla
  - Bertrand Séraphin
  - José Manuel Pérez-Cañadillas
  Nucleic Acids Research ; Volume: 44 ; Page: 437-448
  HAL DOI
2015
- Loss of the scavenger mRNA decapping enzyme DCPS causes syndromic intellectual disability with neuromuscular defects
  - C Ng
  - M Shboul
  - Valerio Taverniti
  - C Bonnard
  - H Lee
  - A Eskin
  - S Nelson
  - M Al-Raqad
  - S Altawalbeh
  - Bertrand Séraphin
  - B Reversade
  Human Molecular Genetics ; Volume: 24 ; Page: 3163-3171
  HAL DOI
- Elimination of cap structures generated by mRNA decay involves the new scavenger mRNA decapping enzyme Aph1/FHIT together with DcpS
  - Valerio Taverniti
  - Bertrand Séraphin
  Nucleic Acids Research ; Volume: 43 ; Page: 482-492
  HAL DOI
- Structure of the Elongator cofactor complex Kti11/Kti13 provides insight into the role of Kti13 in Elongator-dependent tRNA modification
  - Olga Kolaj-Robin
  - A Mcewen
  - Jean Cavarelli
  - Bertrand Séraphin
  FEBS Journal ; Volume: 282 ; Page: 819-833
  HAL DOI

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3'-5' RNA decay and effects on pathologies