3'-5' RNA decay and effects on pathologies

While the main mRNA decay pathway involves the 5’ to 3’ degradation of the mRNA body, 3’ to 5’ exonucleolytic mRNA trimming has been shown to play a major role for the elimination of defective, poorly translatable transcripts. Factors involved in the latter pathway are altered in a rare human genetic disease, underlining its importance. In this context, we are testing the role of these factors in pathological conditions. Moreover, we have identified new factors associated with 3’-5’ mRNA decay and are actively pursuing their characterization.