Department : Functional genomics and cancer
After my PhD thesis in 2002, I worked as a post-doc in different laboratories, in the US (La Jolla Institute, San Diego, CA) and in Europe (IMMZ, Freiburg, Germany and Cochin Institute, Paris, France) to gain skills and experience. I am a permanent researcher at the CNRS since 2013. During my professional career, I studied various topics, such as the molecular mechanisms of cell death and proliferation, CD4+ T cell activation and their differentiation into distinct sub-populations of effector lymphocytes (such as Th17 cells).
Since my arrival in the laboratory of Susan Chan and Philippe Kastner, I am pursuing projects focusing on understanding how the Ikaros family members influence the fate of murine and human CD4+ T cells in physiological and pathological conditions. For this aim, we are using genetically engineered models, combined with different technical approaches, ranging from molecular and cellular biology and genome wide studies (ChIP-seq, ATAC-seq, RNA-seq). We recently showed that Ikaros is required 1) to promote CD4+ T cells polarization into IL-17-secreting Th17 cells, and 2) to inhibit the expression of pro-inflammatory cytokines (i.e. GM-CSF and IFN) and repress the pathogenic phenotype of CD4+ T cells. We now want to determine the molecular mechanisms by which Ikaros influences the fate of CD4+ T cells and extend our findings to better understand the development of inflammatory and autoimmune diseases.