B Cells

After obtaining my Master degree in Technical Biology at the University of Stuttgart, I entered the world of B lymphocytes by joining the laboratory of Michael Reth at the Max Planck Institute for Immunobiology and Epigenetics (Freiburg, Germany). My research focused on B cell receptor signal transduction and I obtained my PhD degree from the University of Freiburg in 2010. I then moved to the IGBMC (Illkirch, France) to do my Post-doc in the lab of Susan Chan and Philippe Kastner working on the role of Ikaros in early B cell differentiation. Since 2016, I am a permanent researcher (Inserm) at the IGBMC and responsible for all the B cell project of the team. I am interested in understanding how the Ikaros family directs B cell differentiation and function and which alterations are implicated in human pathologies e.g. acute lymphoblastic leukemia. To study the function of the Ikaros family, genome wide approaches such as ChIP-Seq and ATAC-Seq but also mechanistically studies at the molecular level are applied in murine and human systems.