Eukaryotic mRNA decay
Team Leader : Bertrand SERAPHIN
Department : Executive management
SUBGROUP LEADER
In eukaryotes, mRNA decay is intimately associated with translation. The latter process relies on specific marks to be efficient, namely the 5’ mRNA cap and the 3’ poly(A) tail. These characteristic modifications that delimits full mRNAs become ultimately the targets of the mRNA decay machinery. We are investigating how mRNA decay factors interact and/or interfere with the translation apparatus and how RNA modifications affect translation.
EMBO Reports ; Volume: 18 ; Page: 264-279
Enzymes ; Volume: 41 ; Page: 117-149
Nature Structural and Molecular Biology ; Volume: 23 ; Page: 982-986
Molecular Cell ; Volume: 63 ; Page: 927-38
Nature Structural and Molecular Biology ; Page: 794-802
Nature Communications ; Volume: 7
Nucleic Acids Research ; Volume: 44 ; Page: 437-448
Human Molecular Genetics ; Volume: 24 ; Page: 3163-3171
Nucleic Acids Research ; Volume: 43 ; Page: 482-492
FEBS Journal ; Volume: 282 ; Page: 819-833
Page 2 of 5