Eukaryotic mRNA decay
Team Leader : Bertrand SERAPHIN
Department : Functional genomics and cancer
Translation/modification/RNA decay links
Translation/modification/RNA decay links
SUBGROUP LEADER
In eukaryotes, mRNA decay is intimately associated with translation. The latter process relies on specific marks to be efficient, namely the 5’ mRNA cap and the 3’ poly(A) tail. These characteristic modifications that delimits full mRNAs become ultimately the targets of the mRNA decay machinery. We are investigating how mRNA decay factors interact and/or interfere with the translation apparatus and how RNA modifications affect translation.
Teams
Members
Researchers
Engineers
Publications
2016
Structure of the active form of Dcp1–Dcp2 decapping enzyme bound to m7GDP and its Edc3 activator
- Clément Charenton
- Valerio Taverniti
- Claudine Gaudon-Plesse
- Régis Back
- Bertrand Séraphin
- Marc Graille
Nature Structural and Molecular Biology ; Volume: 23 ; Page: 982-986
Acetylation-Dependent Control of Global Poly(A) RNA Degradation by CBP/p300 and HDAC1/2
- Sahil Sharma
- Fabian Poetz
- Marius Bruer
- Thi Bach Nga Ly-Hartig
- Johanna Schott
- Bertrand Séraphin
- Georg Stoecklin
Molecular Cell ; Volume: 63 ; Page: 927-38
Structural basis for tRNA modification by Elp3 from Dehalococcoides mccartyi
- Sebastian Glatt
- Rene Zabel
- Olga Kolaj-Robin
- Osita Onuma
- Florence Baudin
- Andrea Graziadei
- Valério Taverniti
- Yu-Ting Lin
- Frauke Baymann
- Bertrand Séraphin
- Karin D Breunig
- Christoph W Müller
Nature Structural and Molecular Biology ; Page: 794-802
BTG2 bridges PABPC1 RNA-binding domains and CAF1 deadenylase to control cell proliferation
- Benjamin Stupfler
- Catherine Birck
- Bertrand Séraphin
- Fabienne Mauxion
Nature Communications ; Volume: 7
Gbp2 interacts with THO/TREX through a novel type of RRM domain
- Santiago Martínez-Lumbreras
- Valério Taverniti
- Silvia Zorrilla
- Bertrand Séraphin
- José Manuel Pérez-Cañadillas
Nucleic Acids Research ; Volume: 44 ; Page: 437-448
2015
Loss of the scavenger mRNA decapping enzyme DCPS causes syndromic intellectual disability with neuromuscular defects
- C Ng
- M Shboul
- Valerio Taverniti
- C Bonnard
- H Lee
- A Eskin
- S Nelson
- M Al-Raqad
- S Altawalbeh
- Bertrand Séraphin
- B Reversade
Human Molecular Genetics ; Volume: 24 ; Page: 3163-3171
Elimination of cap structures generated by mRNA decay involves the new scavenger mRNA decapping enzyme Aph1/FHIT together with DcpS
- Valerio Taverniti
- Bertrand Séraphin
Nucleic Acids Research ; Volume: 43 ; Page: 482-492
Structure of the Elongator cofactor complex Kti11/Kti13 provides insight into the role of Kti13 in Elongator-dependent tRNA modification
- Olga Kolaj-Robin
- A Mcewen
- Jean Cavarelli
- Bertrand Séraphin
FEBS Journal ; Volume: 282 ; Page: 819-833
2014
The C-Terminal Domain from S. cerevisiae Pat1 Displays Two Conserved Regions Involved in Decapping Factor Recruitment
- Zaineb Fourati
- Olga A Kolesnikova
- Régis Back
- Jenny Keller
- Clément Charenton
- Valério Taverniti
- Claudine Gaudon Plesse
- Noureddine Lazar
- Dominique Durand
- Herman van Tilbeurgh
- Bertrand Séraphin
- Marc Graille
PLoS ONE ; Volume: 9 ; Page: e96828
Long open reading frame transcripts escape nonsense-mediated mRNA decay in yeast
- Laurence Decourty
- Antonia Doyen
- Christophe Malabat
- Emmanuel Frachon
- Delphine Rispal
- Bertrand Séraphin
- Frank Feuerbach
- Alain Jacquier
- Cosmin Saveanu
Cell Reports ; Volume: 6 ; Page: 593--598