Eukaryotic mRNA decay
Team Leader : Bertrand SERAPHIN
Department : Functional genomics and cancer
Translation/modification/RNA decay links
Translation/modification/RNA decay links
SUBGROUP LEADER
In eukaryotes, mRNA decay is intimately associated with translation. The latter process relies on specific marks to be efficient, namely the 5’ mRNA cap and the 3’ poly(A) tail. These characteristic modifications that delimits full mRNAs become ultimately the targets of the mRNA decay machinery. We are investigating how mRNA decay factors interact and/or interfere with the translation apparatus and how RNA modifications affect translation.
Teams
Members
Researchers
Engineers
Publications
2014
The C-Terminal Domain from S. cerevisiae Pat1 Displays Two Conserved Regions Involved in Decapping Factor Recruitment
- Zaineb Fourati
- Olga Kolesnikova
- Régis Back
- Jenny Keller
- Clément Charenton
- Valerio Taverniti
- Claudine Plesse
- Noureddine Lazar
- Dominique Durand
- Herman van Tilbeurgh
- Bertrand Séraphin
- Marc Graille
PLoS ONE ; Volume: 9 ; Page: e96828
Dom34-Hbs1 mediated dissociation of inactive 80S ribosomes promotes restart of translation after stress
- A van den Elzen
- A Schuller
- R Green
- Bertrand Séraphin
EMBO Journal ; Volume: 33 ; Page: 265-276
Quantification of pre-mRNA escape rate and synergy in splicing
- Marie Mi Bonde
- S Voegeli
- A Baudrimont
- Bertrand Séraphin
- A Becskei
Nucleic Acids Research ; Volume: 42 ; Page: 12847-12860
A novel protein-protein interaction in the RES (REtention and Splicing) complex
- K Tripsianes
- A Friberg
- C Barrandon
- M Brooks
- H van Tilbeurgh
- Bertrand Séraphin
- M Sattler
Journal of Biological Chemistry ; Volume: 289 ; Page: 28640-28650
2013
Identification of the Rps28 binding motif from yeast Edc3 involved in the autoregulatory feedback loop controlling RPS28B mRNA decay.
- Olga Kolesnikova
- Régis Back
- Marc Graille
- Bertrand Séraphin
Nucleic Acids Research ; Volume: 41 ; Page: 9514-9523
Identification of the Rps28 binding motif from yeast Edc3 involved in the autoregulatory feedback loop controlling RPS28B mRNA decay
- Olga Kolesnikova
- Régis Back
- Marc Graille
- Bertrand Séraphin
Nucleic Acids Research ; Volume: 41 ; Page: 9514 - 9523
Rapid screening of yeast mutants with reporters identifies new splicing phenotypes
- Natacha Dreumont
- Bertrand Séraphin
FEBS Journal ; Volume: 280 ; Page: 2712-2726
Structure and RNA-binding properties of the Not1-Not2-Not5 module of the yeast Ccr4-Not complex
- V Bhaskar
- Vladimir Roudko
- J Basquin
- K Sharma
- H Urlaub
- Bertrand Séraphin
- E Conti
Nature Structural and Molecular Biology ; Volume: 20 ; Page: 1281-1288
Intracellular ribonucleases involved in transcript processing and decay: precision tools for RNA
- C Arraiano
- Fabienne Mauxion
- S Viegas
- R Matos
- Bertrand Séraphin
BBA - Biochimica et Biophysica Acta ; Volume: 1829 ; Page: 491-513
C2ORF29/CNOT11 and CNOT10 form a new module of the CCR4-NOT complex
- Fabienne Mauxion
- B Preve
- Bertrand Séraphin
RNA biology ; Volume: 10 ; Page: 267-276