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Translation/modification/RNA decay links

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Teams
Members
Publications

Translation/modification/RNA decay links

SUBGROUP LEADER

Bertrand SERAPHIN

In eukaryotes, mRNA decay is intimately associated with translation. The latter process relies on specific marks to be efficient, namely the 5’ mRNA cap and the 3’ poly(A) tail. These characteristic modifications that delimits full mRNAs become ultimately the targets of the mRNA decay machinery. We are investigating how mRNA decay factors interact and/or interfere with the translation apparatus and how RNA modifications affect translation.

Teams

Eukaryotic mRNA decay
Team Leader : Bertrand SERAPHIN
Department : Executive management

Members

Researchers

Engineers

Claudine GAUDON-PLESSE

Publications

2014
- The C-Terminal Domain from S. cerevisiae Pat1 Displays Two Conserved Regions Involved in Decapping Factor Recruitment
  - Zaineb Fourati
  - Olga A Kolesnikova
  - Régis Back
  - Jenny Keller
  - Clément Charenton
  - Valério Taverniti
  - Claudine Gaudon Plesse
  - Noureddine Lazar
  - Dominique Durand
  - Herman van Tilbeurgh
  - Bertrand Séraphin
  - Marc Graille
  PLoS ONE ; Volume: 9 ; Page: e96828
  HAL DOI
- Long open reading frame transcripts escape nonsense-mediated mRNA decay in yeast
  - Laurence Decourty
  - Antonia Doyen
  - Christophe Malabat
  - Emmanuel Frachon
  - Delphine Rispal
  - Bertrand Séraphin
  - Frank Feuerbach
  - Alain Jacquier
  - Cosmin Saveanu
  Cell Reports ; Volume: 6 ; Page: 593--598
  HAL DOI
- The C-Terminal Domain from S. cerevisiae Pat1 Displays Two Conserved Regions Involved in Decapping Factor Recruitment
  - Zaineb Fourati
  - Olga Kolesnikova
  - Régis Back
  - Jenny Keller
  - Clément Charenton
  - Valerio Taverniti
  - Claudine Plesse
  - Noureddine Lazar
  - Dominique Durand
  - Herman van Tilbeurgh
  - Bertrand Séraphin
  - Marc Graille
  PLoS ONE ; Volume: 9 ; Page: e96828
  HAL DOI
- Dom34-Hbs1 mediated dissociation of inactive 80S ribosomes promotes restart of translation after stress
  - A van den Elzen
  - A Schuller
  - R Green
  - Bertrand Séraphin
  EMBO Journal ; Volume: 33 ; Page: 265-276
  HAL DOI
- Quantification of pre-mRNA escape rate and synergy in splicing
  - Marie Mi Bonde
  - S Voegeli
  - A Baudrimont
  - Bertrand Séraphin
  - A Becskei
  Nucleic Acids Research ; Volume: 42 ; Page: 12847-12860
  HAL DOI
- A novel protein-protein interaction in the RES (REtention and Splicing) complex
  - K Tripsianes
  - A Friberg
  - C Barrandon
  - M Brooks
  - H van Tilbeurgh
  - Bertrand Séraphin
  - M Sattler
  Journal of Biological Chemistry ; Volume: 289 ; Page: 28640-28650
  HAL DOI
2013
- Identification of the Rps28 binding motif from yeast Edc3 involved in the autoregulatory feedback loop controlling RPS28B mRNA decay.
  - Olga Kolesnikova
  - Régis Back
  - Marc Graille
  - Bertrand Séraphin
  Nucleic Acids Research ; Volume: 41 ; Page: 9514-9523
  HAL DOI
- Identification of the Rps28 binding motif from yeast Edc3 involved in the autoregulatory feedback loop controlling RPS28B mRNA decay
  - Olga Kolesnikova
  - Régis Back
  - Marc Graille
  - Bertrand Séraphin
  Nucleic Acids Research ; Volume: 41 ; Page: 9514 - 9523
  HAL DOI
- Rapid screening of yeast mutants with reporters identifies new splicing phenotypes
  - Natacha Dreumont
  - Bertrand Séraphin
  FEBS Journal ; Volume: 280 ; Page: 2712-2726
  HAL DOI
- Structure and RNA-binding properties of the Not1-Not2-Not5 module of the yeast Ccr4-Not complex
  - V Bhaskar
  - Vladimir Roudko
  - J Basquin
  - K Sharma
  - H Urlaub
  - Bertrand Séraphin
  - E Conti
  Nature Structural and Molecular Biology ; Volume: 20 ; Page: 1281-1288
  HAL DOI

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