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Translation/modification/RNA decay links

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Teams
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Publications

Translation/modification/RNA decay links

SUBGROUP LEADER

Bertrand SERAPHIN

In eukaryotes, mRNA decay is intimately associated with translation. The latter process relies on specific marks to be efficient, namely the 5’ mRNA cap and the 3’ poly(A) tail. These characteristic modifications that delimits full mRNAs become ultimately the targets of the mRNA decay machinery. We are investigating how mRNA decay factors interact and/or interfere with the translation apparatus and how RNA modifications affect translation.

Teams

Eukaryotic mRNA decay
Team Leader : Bertrand SERAPHIN
Department : Executive management

Members

Researchers

Publications

2012
- Extensive degradation of RNA precursors by the exosome in wild-type cells.
  - Rajani Kanth Gudipati
  - Zhenyu Xu
  - Alice Lebreton
  - Bertrand Séraphin
  - Lars M Steinmetz
  - Alain Jacquier
  - Domenico Libri
  Molecular Cell ; Volume: 48 ; Page: 409-21
  HAL DOI
- Surveillance pathways rescuing eukaryotic ribosomes lost in translation
  - Marc Graille
  - Bertrand Séraphin
  Nature Reviews Molecular Cell Biology ; Volume: 13 ; Page: 727–735
  HAL DOI
- The Elongator subcomplex Elp456 is a hexameric RecA-like ATPase
  - S Glatt
  - J Letoquart
  - C Faux
  - N Taylor
  - Bertrand Séraphin
  - C Muller
  Nature Structural and Molecular Biology ; Volume: 19 ; Page: 314-320
  HAL DOI
- Elongator: transcriptional or translational regulator?
  - S Glatt
  - Bertrand Séraphin
  - C Muller
  Transcription ; Volume: 3 ; Page: 273-276
  HAL DOI
- Microbial proteomics: the quiet revolution
  - Bertrand Séraphin
  - R Hettich
  Current opinion in microbiology ; Volume: 15 ; Page: 348-350
  HAL DOI
- Architecture of the nuclease module of the yeast Ccr4-not complex: the Not1-Caf1-Ccr4 interaction
  - J Basquin
  - Vladimir Roudko
  - M Rode
  - C Basquin
  - Bertrand Séraphin
  - Eric Conti
  Molecular Cell ; Volume: 48 ; Page: 207-218
  HAL DOI
- Rbg1-Tma46 dimer structure reveals new functional domains and their role in polysome recruitment
  - S Francis
  - M Gas
  - Marie-Claire Daugeron
  - J Bravo
  - Bertrand Séraphin
  Nucleic Acids Research ; Volume: 40 ; Page: 11100-11114
  HAL DOI
- Surveillance pathways rescuing eukaryotic ribosomes lost in translation
  - Marc Graille
  - Bertrand Séraphin
  Nature Reviews Molecular Cell Biology ; Volume: 13 ; Page: 727-735
  HAL DOI
2011
- The highly conserved eukaryotic DRG factors are required for efficient translation in a manner redundant with the putative RNA helicase Slh1
  - Marie-Claire Daugeron
  - Manoël Prouteau
  - François Lacroute
  - Bertrand Séraphin
  Nucleic Acids Research ; Volume: 39 ; Page: 2221-2233
  HAL DOI
- Cotranscriptional spliceosome assembly and splicing are independent of the Prp40p WW domain
  - J Gornemann
  - C Barrandon
  - K Hujer
  - B Rutz
  - G Rigaut
  - K Kotovic
  - C Faux
  - K Neugebauer
  - Bertrand Séraphin
  RNA ; Volume: 17 ; Page: 2119-2129
  HAL DOI

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