Eukaryotic mRNA decay
Team Leader : Bertrand SERAPHIN
Department : Functional genomics and cancer
Translation/modification/RNA decay links
Translation/modification/RNA decay links
SUBGROUP LEADER
In eukaryotes, mRNA decay is intimately associated with translation. The latter process relies on specific marks to be efficient, namely the 5’ mRNA cap and the 3’ poly(A) tail. These characteristic modifications that delimits full mRNAs become ultimately the targets of the mRNA decay machinery. We are investigating how mRNA decay factors interact and/or interfere with the translation apparatus and how RNA modifications affect translation.
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Researchers
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Publications
2012
Extensive degradation of RNA precursors by the exosome in wild-type cells.
- Rajani Kanth Gudipati
- Zhenyu Xu
- Alice Lebreton
- Bertrand Séraphin
- Lars M Steinmetz
- Alain Jacquier
- Domenico Libri
Molecular Cell ; Volume: 48 ; Page: 409-21
Surveillance pathways rescuing eukaryotic ribosomes lost in translation
- Marc Graille
- Bertrand Séraphin
Nature Reviews Molecular Cell Biology ; Volume: 13 ; Page: 727–735
The Elongator subcomplex Elp456 is a hexameric RecA-like ATPase
- S Glatt
- J Letoquart
- C Faux
- N Taylor
- Bertrand Séraphin
- C Muller
Nature Structural and Molecular Biology ; Volume: 19 ; Page: 314-320
Elongator: transcriptional or translational regulator?
- S Glatt
- Bertrand Séraphin
- C Muller
Transcription ; Volume: 3 ; Page: 273-276
Microbial proteomics: the quiet revolution
- Bertrand Séraphin
- R Hettich
Current opinion in microbiology ; Volume: 15 ; Page: 348-350
Architecture of the nuclease module of the yeast Ccr4-not complex: the Not1-Caf1-Ccr4 interaction
- J Basquin
- Vladimir Roudko
- M Rode
- C Basquin
- Bertrand Séraphin
- Eric Conti
Molecular Cell ; Volume: 48 ; Page: 207-218
Rbg1-Tma46 dimer structure reveals new functional domains and their role in polysome recruitment
- S Francis
- M Gas
- Marie-Claire Daugeron
- J Bravo
- Bertrand Séraphin
Nucleic Acids Research ; Volume: 40 ; Page: 11100-11114
Surveillance pathways rescuing eukaryotic ribosomes lost in translation
- Marc Graille
- Bertrand Séraphin
Nature Reviews Molecular Cell Biology ; Volume: 13 ; Page: 727-735
2011
The highly conserved eukaryotic DRG factors are required for efficient translation in a manner redundant with the putative RNA helicase Slh1
- Marie-Claire Daugeron
- Manoël Prouteau
- François Lacroute
- Bertrand Séraphin
Nucleic Acids Research ; Volume: 39 ; Page: 2221-2233
Cotranscriptional spliceosome assembly and splicing are independent of the Prp40p WW domain
- J Gornemann
- C Barrandon
- K Hujer
- B Rutz
- G Rigaut
- K Kotovic
- C Faux
- K Neugebauer
- Bertrand Séraphin
RNA ; Volume: 17 ; Page: 2119-2129