Eukaryotic mRNA decay
Team Leader : Bertrand SERAPHIN
Department : Functional genomics and cancer
Translation/modification/RNA decay links
Translation/modification/RNA decay links
SUBGROUP LEADER
In eukaryotes, mRNA decay is intimately associated with translation. The latter process relies on specific marks to be efficient, namely the 5’ mRNA cap and the 3’ poly(A) tail. These characteristic modifications that delimits full mRNAs become ultimately the targets of the mRNA decay machinery. We are investigating how mRNA decay factors interact and/or interfere with the translation apparatus and how RNA modifications affect translation.
Teams
Members
Researchers
Engineers
Publications
2011
Catalytic properties of the eukaryotic exosome
- A Chlebowski
- R Tomecki
- Maria Gas Lopez
- Bertrand Séraphin
- A Dziembowski
Advances in Experimental Medicine and Biology ; Volume: 702 ; Page: 63-78
Strategies for the structural analysis of multi-protein complexes: lessons from the 3D-Repertoire project
- B Collinet
- A Friberg
- M Brooks
- T van de Elzen
- V Henriot
- A Dziembowski
- M Graille
- D Durand
- N Leulliot
- C Saint Andre
- N Lazar
- M Sattler
- Bertrand Séraphin
- H van Tilbeurgh
Journal of Structural Biology ; Volume: 175 ; Page: 147-158
2010
Structural and Functional Insights into Saccharomyces cerevisiae Tpa1, a Putative Prolylhydroxylase Influencing Translation Termination and Transcription
- Julien Henri
- Delphine Rispal
- Emilie Bayart
- Herman van Tilbeurgh
- Bertrand Séraphin
- Marc Graille
Journal of Biological Chemistry ; Volume: 285 ; Page: 30767-30778
Dissection of Dom34–Hbs1 reveals independent functions in two RNA quality control pathways
- Antonia M G van den Elzen
- Julien Henri
- Noureddine Lazar
- María Eugenia Gas
- Dominique Durand
- François Lacroute
- Magali Nicaise
- Herman van Tilbeurgh
- Bertrand Séraphin
- Marc Graille
Nature Structural and Molecular Biology ; Volume: 17 ; Page: 1446 - 1452
Structural and Functional Insights into Saccharomyces cerevisiae Tpa1, a Putative Prolylhydroxylase Influencing Translation Termination and Transcription
- Julien Henri
- Delphine Rispal
- Emilie Bayart
- Herman van Tilbeurgh
- Bertrand Séraphin
- Marc Graille
Journal of Biological Chemistry ; Volume: 285 ; Page: 30767 - 30778
2005
The exon junction core complex is locked onto RNA by inhibition of eIF4AIII ATPase activity.
- Lionel Ballut
- Brice Marchadier
- Aurélie Baguet
- Catherine Tomasetto
- Bertrand Séraphin
- Hervé Le Hir
Nature Structural and Molecular Biology ; Volume: 12 ; Page: 861-9