Chromatin and epigenetic regulation
Chromatin and epigenetic regulation
The main research activity of our group is to study the role of histone variants and their deposition machineries in the epigenetic control of human genome activity at the genome- wide level. Among the various epigenetic memory mechanisms, the local replacement of canonical histones within the nucleosome by variant histones has the potential to affect considerably the activity of the corresponding genomic regions. Indeed, nucleosomes bearing histone variants have distinct structures and functional activities in vitro and some histone variants are incorporated at specific genomic locations. Our laboratory is focusing on the role of histone variants in gene regulation and genome integrity. We have recently implicated macroH2A in PARP-1 enzymatic activity and transcription regulation (Ouararhni et al., 2006), and discovered a new link between histone variants, transcription factors and non- coding RNA (unpublished results). This association with transcription factors and non-coding RNA is novel and will certainly help us to understand how chromatin domains are established and how epigenetic information is stored and transmitted to daughter cells. Alteration of these epigenetic marks is associated with developmental disorders and cancer.
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News
The quaternary structure of the GR highlights inter-domain allosteric communication
In inflammatory or autoimmune diseases, modulating the action of the glucocorticoid receptor (GR) is an effective therapeutic strategy. However, the…
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Publications
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2020
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H2A.Z is dispensable for both basal and activated transcription in post-mitotic mouse muscles
- Edwige Belotti
- Nicolas Lacoste
- Thomas Simonet
- Christophe Papin
- Kiran Padmanabhan
- Isabella Scionti
- Yann-Gaël Gangloff
- Lorrie Ramos
- Defne Dalkara
- Ali Hamiche
- Stefan Dimitrov
- Laurent Schaeffer
Nucleic Acids Research ; Volume: 48 ; Page: 4601 - 4613
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Cryo-electron microscopy of the chromatin fiber
- Ramachandran Boopathi
- Stefan Dimitrov
- Ali Hamiche
- Carlo Petosa
- Jan Bednar
Current Opinion in Structural Biology ; Volume: 64 ; Page: 97-103
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2019
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Generation of Remosomes by the SWI/SNF Chromatin Remodeler Family
- Manu Shubhdarshan Shukla
- Sajad Hussain Syed
- Ramachandran Boopathi
- Elsa Ben Simon
- Sunil Nahata
- Lorrie Ramos
- Defne Dalkara
- Cendrine Moskalenko
- Andrew Travers
- Dimitar Angelov
- Stefan Dimitrov
- Ali Hamiche
- Jan Bednar
Scientific Reports ; Volume: 9 ; Page: 14212
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CENP-A nucleosome clusters form rosette-like structures around HJURP during G1
- Leonid Andronov
- Khalid Ouararhni
- Isabelle Stoll
- Bruno P. Klaholz
- Ali Hamiche
Nature Communications ; Volume: 10 ; Page: 4436
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Coordinated Dialogue between UHRF1 and DNMT1 to Ensure Faithful Inheritance of Methylated DNA Patterns
- Ali Hamiche
- Christian Bronner
- Mahmoud Alhosin
- Marc Mousli
Genes ; Volume: 10 ; Page: 65
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Centromeric and ectopic assembly of CENP-A chromatin in health and cancer: old marks and new tracks
- A Sharma
- S Dimitrov
- Ali Hamiche
- E van Dyck
Nucleic Acids Research ; Volume: 47 ; Page: 1051-1069
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2018
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Structure of an H1-Bound 6-Nucleosome Array Reveals an Untwisted Two-Start Chromatin Fiber Conformation
- Isabel Garcia-Saez
- Hervé Menoni
- Ramachandran Boopathi
- Manu Shukla
- Lama Soueidan
- Marjolaine Noirclerc-Savoye
- Aline Le Roy
- Dimitrios Skoufias
- Jan Bednar
- Ali Hamiche
- Dimitar Angelov
- Carlo Petosa
- Stefan Dimitrov
Molecular Cell ; Volume: 72 ; Page: 902-915.e7
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3DClusterViSu: 3D clustering analysis of super-resolution microscopy data by 3D Voronoi tessellations
- Leonid Andronov
- Jonathan Michalon
- Khalid Ouararhni
- Igor Orlov
- Ali Hamiche
- Jean-Luc Vonesch
- Bruno P. Klaholz
Bioinformatics ; Volume: 34 ; Page: 3004-3012
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Thymoquinone challenges UHRF1 to commit auto-ubiquitination: a key event for apoptosis induction in cancer cells
- Abdulkhaleg Ibrahim
- Mahmoud Alhosin
- Christophe Papin
- Khalid Ouararhni
- Ziad Omran
- Mazin A. Zamzami
- Abdulrahman Labeed Al-Malki
- Hani Choudhry
- Yves Mély
- Ali Hamiche
- Marc Mousli
- Christian Bronner
Oncotarget ; Volume: 9 ; Page: 28599-28611
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Identification of Deregulated Signaling Pathways in Jurkat Cells in Response to a Novel Acylspermidine Analogue-N 4 -Erucoyl Spermidine
- Ali Hamiche
- Syed Shoeb Razvi
- Hani Choudhry
- Mohammed Nihal Hasan
- Mohammed Hassan
- Said Salama Moselhy
- Khalid Omer Abualnaja
- Mazin Zamzami
- Taha Abduallah Kumosani
- Abdulrahman Labeed Al-Malki
- Majed Halwani
- Abdulkhaleg Ibrahim
- Christian Bronner
- Tadao Asami
- Mahmoud Alhosin
Epigenetics Insights ; Volume: 11 ; Page: 251686571881454
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