Factors and RNA modifications regulating mRNA decay
Subgroup Leader : Bertrand SERAPHIN
Teams : Eukaryotic mRNA decay
We are interested to unravel the mechanisms controlling eukaryotic gene expression at the level of RNA decay. Those contribute to the regulation of gene expression as changes in the local decay rate of specific messenger RNAs (mRNAs) most often result in cognate changes in the level of the corresponding protein through the modulation of the level of the mRNA template available to ribosomes. Thus, changes in mRNA degradation may affect in a timely manner the quantity of protein synthesized, but also contribute to the localized expression of specific factors (e.g., during development). Besides its quantitative role in controlling mRNA levels, RNA decay also performs a second qualitative function through the elimination of aberrant or damaged RNA molecules.
Several pathways implicated in the degradation of eukaryotic RNAs have been identified. The main pathway for the degradation of « normal » mRNAs is multistep, being initiated by the removal of the mRNA poly(A) tail, a process coined deadenylation, and usually followed by decapping before the degradation of the mRNA body in the 5’-3’ direction. Alternatively, after deadenylation, the mRNA body can be degraded by a minor pathway in the 3’-5’ direction. If many enzymes involved in mRNA decay are now known, some remain to be identified. Moreover, mechanisms activating specific enzymes in defined conditions need also to be elucidated. Finally, we are also interested in deciphering the coordination of mRNA decay with other cellular processes such as translation and in characterizing diseases resulting from alteration of this process.
Subgroup Leader : Bertrand SERAPHIN
Teams : Eukaryotic mRNA decay
Subgroup Leader : Fabienne MAUXION
Teams : Eukaryotic mRNA decay
Subgroup Leader : Eric HUNTZINGER
Teams : Eukaryotic mRNA decay
Subgroup Leader : Bertrand SERAPHIN
Teams : Eukaryotic mRNA decay
Bertrand Séraphin
Eric Huntzinger
In addition to those common to everyone in the institute:
B. Séraphin
In humans, a viral infection induces a response to protect the body, resulting in the production of a signal molecule: interferon. Interferon induces…
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