Structure function of complexes involved in the HIV replication cycle, drug design

Publications

• 2018

  • Post-translational modifications in DNA topoisomerase 2α highlight the role of a eukaryote-specific residue in the ATPase domain

    • Claire Bedez
    • Christophe Lotz
    • Claire Batisse
    • Arnaud Vanden Broeck
    • Roland Stote
    • Eduardo Howard
    • Karine Pradeau Aubreton
    • Marc Ruff
    • Valerie Lamour

    Scientific Reports ; Volume: 8

    HAL DOI

  • Genetic Flexibility of the NKNK Motif in HIV-1 Integrases Allows Its Involvement in Multiple Functions During Infection

    • Marine Kanja
    • Pierre Cappy
    • Guillermo Blanco-Rodriguez
    • Nicolas Levy
    • Sylvie Schmidt
    • Romain Gasser
    • Paola Rossolillo
    • Christiane Moog
    • M. Ruff
    • Francesca Di Nunzio
    • Matteo Negroni
    • Daniela Lener

    Synthetic Biology eJournal

    HAL DOI

  • Structure-function analyses unravel distinct effects of allosteric inhibitors of HIV-1 integrase on viral maturation and integration

    • Damien Bonnard
    • Erwann Le Rouzic
    • Sylvia Eiler
    • Céline Amadori
    • Igor Orlov
    • Jean-Michel Bruneau
    • Julie Brias
    • Julien Barbion
    • Francis Chevreuil
    • Daniele Spehner
    • Sophie Chasset
    • Benoit Ledoussal
    • François Moreau
    • Ali Saib
    • Bruno P. Klaholz
    • Stéphane Emiliani
    • Marc Ruff
    • Alessia Zamborlini
    • Richard Benarous

    Journal of Biological Chemistry ; Volume: 293 ; Page: 6172-6186

    HAL DOI

  • Unstable Protein Purification Through the Formation of Stable Complexes

    • Sylvia Eiler
    • Nicolas Lévy
    • Benoit Maillot
    • Julien Batisse
    • Karine Pradeau Aubreton
    • Oyindamola Oladosu
    • Marc Ruff

    Methods in Molecular Biology ; Page: 315-328

    HAL DOI

  • Toward High Resolution Structures of the HIV-1 In/LEDGF/DNA Complex

    • Julien Batisse
    • Eduardo Bruch
    • Nicolas Lévy
    • Benoit Maillot
    • Sylvia Eiler
    • Oyindamola Oladosu
    • Marc Ruff

    Biophysical Journal ; Volume: 114 ; Page: 218a

    HAL DOI

• 2017

  • The HIV-1 integrase-LEDGF allosteric inhibitor MUT-A: resistance profile, impairment of virus maturation and infectivity but without influence on RNA packaging or virus immunoreactivity

    • Céline Amadori
    • Yme Ubeles van Der Velden
    • Damien Bonnard
    • Igor Orlov
    • Nikki van Bel
    • Erwann Le Rouzic
    • Laia Miralles
    • Julie Brias
    • Francis Chevreuil
    • Daniele Spehner
    • Sophie Chasset
    • Benoit Ledoussal
    • Luzia Mayr
    • François Moreau
    • Felipe García
    • José Gatell
    • Alessia Zamborlini
    • Stéphane Emiliani
    • Marc Ruff
    • Bruno P. Klaholz
    • ...

    Retrovirology ; Volume: 14 ; Page: 50

    HAL DOI

  • Modulation of chromatin structure by the FACT histone chaperone complex regulates HIV-1 integration

    • Julien Matysiak
    • Paul Lesbats
    • Eric Mauro
    • Delphine Lapaillerie
    • Jean-William Dupuy
    • Angelica P. Lopez
    • Mohamed Salah Benleulmi
    • Christina Calmels
    • Marie-Line Andreola
    • Marc Ruff
    • Manuel Llano
    • Olivier Delelis
    • Marc Lavigne
    • Vincent Parissi

    Retrovirology ; Volume: 14 ; Page: 39

    HAL DOI

  • Dynamics of Methylated Cytosine Flipping by UHRF1

    • Christian Bronner
    • Vasyl Kilin
    • Krishna Gavvala
    • Nicolas Barthes
    • Benoît Michel
    • Dongwon Shin
    • Christian Boudier
    • Olivier Mauffret
    • Valeriy Yashchuk
    • Marc Mousli
    • Marc Ruff
    • Florence Granger
    • Sylvia Eiler
    • Yitzhak Tor
    • Alain Burger
    • Yves Mély

    Journal of the American Chemical Society ; Volume: 139 ; Page: 2520-2528

    HAL DOI

  • The HIV-1 Pre-Integration Complexes: Structures, Functions and Dynamics

    • Nicolas Levy
    • Karine Pradeau-Aubreton
    • Sylvia Eiler
    • Julien Batisse
    • Oyindamola Oladosu
    • Benoit Maillot
    • Marc Ruff

    Biophysical Journal ; Volume: 112 ; Page: 30a

    HAL DOI

  • Modulation of the functional association between the HIV-1 intasome and the nucleosome by histone amino-terminal tails

    • Mohamed S Benleulmi
    • Julien Matysiak
    • Xavier Robert
    • Csaba Miskey
    • Eric Mauro
    • Delphine Lapaillerie
    • Paul Lesbats
    • Stéphane Chaignepain
    • Daniel R Henriquez
    • Christina Calmels
    • Oyindamola Oladosu
    • Eloïse Thierry
    • Oscar Leon
    • Marc Lavigne
    • Marie-Line Andreola
    • Olivier Delelis
    • Zoltán Ivics
    • Marc Ruff
    • Patrice Gouet
    • Vincent Parissi

    Retrovirology ; Volume: 14 ; Page: 54

    HAL DOI