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Cell physics

Cell physics

DEPARTMENT

Development and stem cells

TEAM LEADER

Daniel RIVELINE

The Cell Physics team characterizes self-organization of cells, cell motion, cell division, morphogenesis of tissues in vitro and in vivo. The projects involve synergized approaches between theoretical physics, cell biology, microfabrication.

For more details, see : riveline.igbmc.science

Members

Researchers

PhD students

Engineers

Current projects

Self-organisation in living matter : from cell motility and cytokinesis to morphogenesis

 

  • Cell motility: Ratchetaxis and Scallop Theorem

Publications.

How a cell moves from a point A to a point B in the absence of long range gradient.

 

  • Lammelipodia growth promoter: supramolecular compounds specific to actin

Publications.

Synthetic polyamines trigger growth of lamellipodia within minutes (scale bar 20μm).
 

  • Cytokinesis: myosin clusters dynamics and rings constriction across systems

Publications.

 Myosin clusters dynamics determine the evolutions of cytokinetic rings visualized in a single focal plane with micro-fabricated cavities (myosin, scale bar 5μm).

  • Morphogenesis in vitro: collective effects in cells

Publications.

Elongation of an epithelial colony results from nematic fields and topological defects (scale bar 50μm).

 

  • Scaling and injections of fission yeast

Publications.

 
Asymmetric division : Scaling arguments predict the localisation of septum correlated with differences in cell ends (left).
Fission yeast behaves as a balloon and can be injected (right, scale bar 5μm).

  • Reinforcement of focal contacts and cell-cell junctions (adherens junctions and hemidesmosomes)

Publications.
 

Adhesive contacts elongate with local forces within minutes (compare top and bottom, scale bar 5μm).
They recruit adhesion proteins while keeping their matter density constant.

For more details see : riveline.igbmc.science

Collaborations and networks

  • HFSP coordinator 2018 with Alf Honigmann (MPI-CBG Dresden), Anne Grapin-Botton (Danstem, Copenhagen), Masaki Sano (University of Tokyo)
  • SNF 2019 with Olivier Pertz (University of Bern), Damian Brunner (University of Zurich), Karsten Kruse (University of Geneva)

Funding and partners

  • HFSP coordinator 2018 with Alf Honigmann (MPI-CBG Dresden), Anne Grapin-Botton (Danstem, Copenhagen), Masaki Sano (University of Tokyo)
  • SNF 2019 with Olivier Pertz (University of Bern), Damian Brunner (University of Zurich), Karsten Kruse (University of Geneva)

News

A dashboard to study cell movement

Individual cells move in vivo in complex 3D environments. Their motion occurs at zero force and requires symmetry breaking. In this study at the…

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Awards and recognitions

  • HFSP coordinator 2018
  • Fellowship Simone et Cino del Duca 2011
  • ATIP CNRS 2010

Resources

See the website for the Cell Physics Master at the University of Strasbourg

Publications

Development and stem cells - Rare diseases - Regenerative medicine