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Nuclear organisation and division

Nuclear organisation and division

DEPARTMENT

Development and stem cells

TEAM LEADER

Manuel MENDOZA

Living cells have a fascinating ability to generate complex and dynamic internal structures. Nowhere is this property more evident than during cell division: in only a few minutes, cells alter their shape, duplicate and partition their internal components, and divide into two apparently identical halves, which in many cases go on to acquire distinct identities. These dramatic changes need to be carefully coordinated with each other in space and time.

To gain insight into these processes, we focus on two major cell cycle transitions. First, we study how chromosome segregation and cytokinesis are coordinated with each other. In particular, we study how the Aurora-B-dependent “NoCut” checkpoint regulates cytokinesis abscission when chromatin bridges are delayed in the cell division site. Second, we are interested in mechanisms that establish differences in nuclear organization after asymmetric cell division, and in how nuclear pore complexes control the establishment of cell identity.

Members

Researchers

Current projects

  • Molecular characterization of the NoCut checkpoint in normal and cancer cells
  • Control of Cell Identity by Nuclear Pore Acetylation

Funding and partners

  • Ligue Nationale Contre le Cancer
  • Fondation ARC
  • Université de Strasbourg, Institute for Advanced Studies
  • Fondation pour la Recherche Médicale

Awards and recognitions

European Research Council, Starting Grant (2011)

Publications