
Nuclear organisation and division
Nuclear organisation and division
Living cells have a fascinating ability to generate complex and dynamic internal structures. Nowhere is this property more evident than during cell division: in only a few minutes, cells alter their shape, duplicate and partition their internal components, and divide into two apparently identical halves, which in many cases go on to acquire distinct identities. These dramatic changes need to be carefully coordinated with each other in space and time.
To gain insight into these processes, we focus on two major cell cycle transitions. First, we study how chromosome segregation and cytokinesis are coordinated with each other. In particular, we study how the Aurora-B-dependent “NoCut” checkpoint regulates cytokinesis abscission when chromatin bridges are delayed in the cell division site. Second, we are interested in mechanisms that establish differences in nuclear organization after asymmetric cell division, and in how nuclear pore complexes control the establishment of cell identity.
Members
Researchers
Post-doctoral fellows
PhD students
Engineers
Former members
- Gabriel Neurohr (Group Leader at ETH Zurich)
- Iris Titos (Research Fellow, Department of Neurobiology, Harvard Medical School)
- Nuno Amaral (Technical Writer, Sweden)
- Aina Masgrau (Senior Validation Consultant, Spain)
- Andrea Battola (Medical Affairs Manager, Italy)
- Michael Maier (Postdoctoral Researcher, Institute of Medical Biology, Singapore)
- Francesca Di Giovanni (Technical Support Scientist, France)
- Tsvetomira Ivanova
- Arun Kumar (Postdoctoral Researcher, Cell and Molecular Biology Program, Pompeu Fabra University, Spain)
- Petra Stockinger (Research and Development Specialist, Spain)
- Zhanna Shcheprova (Senior Data Team Lead, France)
- Anne Daulny
- Trinidad Sanmartin (laboratory technician, Institute for Bioengineering of Catalonia, Spain)
- Mercè Gomar (Researcher Juan de la Cierva, University of Valencia, Spain)
- Céline Birling (ingénieur d'études, France)
Current projects
- Molecular characterization of the NoCut checkpoint in normal and cancer cells
- Control of Cell Identity by Nuclear Pore Acetylation
Funding and partners
- French National Research Agency (ANR), Coordinator of Collaborative Research Project, 2022-2025
- ARC Foundation for Cancer Research, « Programme Labellisé », 2022-2025
- FRM Medical Research Foundation, “Equipe Labellisée”, 2021-2024
Awards and recognitions
European Research Council, Starting Grant (2011)
Events
On
11/212023
Publications
2005
Division-Plane Positioning: Microtubules Strike Back
- Manuel Mendoza
- Caren Norden
- Yves Barral
Current Biology - CB ; Volume: 15 ; Page: R595-R597
2002
GTP Binding Induces Filament Assembly of a Recombinant Septin
- Manuel Mendoza
- Anthony Hyman
- Michael Glotzer
Current Biology - CB ; Volume: 12 ; Page: 1858-1863
2000
Incenp and an Aurora-like kinase form a complex essential for chromosome segregation and efficient completion of cytokinesis
- Susanne Kaitna
- Manuel Mendoza
- Verena Jantsch-Plunger
- Michael Glotzer
Current Biology - CB ; Volume: 10 ; Page: 1172-1181
1999
A novel peptide-SH3 interaction
- A. Mongiovi
- P Romano
- S Panni
- Manuel Mendoza
- W Wong
- A Musacchio
- G Cesareni
- P Di Fiore
EMBO Journal ; Volume: 18 ; Page: 5300-5309
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