Transcription complexes variability in development and disease

Research subgroup(s)

Activated transcription
Subgroup Leaders : Adam BEN SHEM , Gabor PAPAI
Teams : Transcription co-activators
Identify the genetic basis of myopathies
Subgroup Leader : Valérie BIANCALANA
Teams : Pathophysiology of neuromuscular diseases
Structural interactomics of steroid nuclear receptors
Subgroup Leader : Isabelle BILLAS MASSOBRIO
Teams : Structural and Quantitative Interactomics
Craniofacial and oral developments, and their associated abnormalities
Subgroup Leader : Agnès BLOCH-ZUPAN
Teams : Pathophysiology of Down's syndrome and rare dose-effect diseases causing intellectual disabilities (ID) or autism spectrum disorders (ASD) and other comorbidities
Understand and cure tubular aggregates myopathy and Stormorken syndrome
Subgroup Leader : Johann BOHM
Teams : Pathophysiology of neuromuscular diseases
Dyrk1a, brain development and rare diseases
Subgroup Leader : Veronique BRAULT
Teams : Pathophysiology of Down's syndrome and rare dose-effect diseases causing intellectual disabilities (ID) or autism spectrum disorders (ASD) and other comorbidities
CBP-Gcm interaction during gliogenesis
Subgroup Leader : Pierre CATTENOZ
Teams : Transcriptional regulation of neural and immune development
Cell Signaling and prostate cancer
Subgroup Leader : Jocelyn CERALINE
Teams : Biomolecular Nuclear Magnetic Resonance
T Cells
Subgroup Leader : Céline CHARVET
Teams : Hematopoiesis and Disease
Biological chemistry of posttranslational modifications in chromatin organization
Subgroup Leader : Christophe DECROOS
Teams : Molecular Basis of Chromatin and Transcription Regulation
Software development and Fluorine NMR, ANR Fluovial
Subgroup Leader : Marc-André DELSUC
Teams : Biomolecular Nuclear Magnetic Resonance
The role of chaperones in maturation and regulation of the androgen receptor, ANR ARCHAP
Subgroup Leader : Célia DEVILLE
Teams : Biomolecular Nuclear Magnetic Resonance
Integrative structural biology of SMC complexes
Subgroup Leader : Marie-Laure DIEBOLD
Teams : Molecular Basis of Chromatin and Transcription Regulation
RNA-mediated targeting and interactomics
Subgroup Leader : Mariel DONZEAU
Teams : Structural and Quantitative Interactomics
Steroid receptor and epigenetic co-regulator function in tissue homeostasis
Subgroup Leader : Delphine DUTEIL
Teams : Pathophysiological role of nuclear receptor signalling
Behavior and social interaction in normal and pathological situations
Subgroup Leader : Elodie EY
Teams : Pathophysiology of Down's syndrome and rare dose-effect diseases causing intellectual disabilities (ID) or autism spectrum disorders (ASD) and other comorbidities
pathophysiology of rare diseases affecting nociception
Subgroup Leader : Claire GAVERIAUX-RUFF
Teams : Pathophysiology of Down's syndrome and rare dose-effect diseases causing intellectual disabilities (ID) or autism spectrum disorders (ASD) and other comorbidities
Personalized systems Cancer Biology
Subgroup Leader : Hinrich GRONEMEYER
Teams : Hematopoiesis and Disease
B Cells
Subgroup Leader : Beate HEIZMANN
Teams : Hematopoiesis and Disease
Aging, Down's syndrome and Alzheimer's disease
Subgroup Leader : Yann HERAULT
Teams : Pathophysiology of Down's syndrome and rare dose-effect diseases causing intellectual disabilities (ID) or autism spectrum disorders (ASD) and other comorbidities
Modeling of "genotype-phenotype" relationships and therapeutic approach in Down syndrome
Subgroup Leader : Yann HERAULT
Teams : Pathophysiology of Down's syndrome and rare dose-effect diseases causing intellectual disabilities (ID) or autism spectrum disorders (ASD) and other comorbidities
neurobiology of 16p11.2 and 17q21.31syndromes and other genetic diseases with ID or ASD
Subgroup Leader : Yann HERAULT
Teams : Pathophysiology of Down's syndrome and rare dose-effect diseases causing intellectual disabilities (ID) or autism spectrum disorders (ASD) and other comorbidities
3'-5' RNA decay and effects on pathologies
Subgroup Leader : Eric HUNTZINGER
Teams : Eukaryotic mRNA decay
Cryo EM studies of the C. elegans ribosome to illuminate structure-function relations of ribosome heterogeneity
Subgroup Leader : Lasse Bohl JENNER
Teams : Molecular Basis for Protein Synthesis by the Ribosome
Fluorine NMR and molecular interactions, ANR PROFLUOR
Subgroup Leader : Bruno KIEFFER
Teams : Biomolecular Nuclear Magnetic Resonance
Stem Cells
Subgroup Leader : Peggy KIRSTETTER
Teams : Hematopoiesis and Disease
MD-PhD programme
Subgroup Leader : Valerie LAMOUR
Teams : Regulation of DNA topology
Structure-fonction of nucleoproteic complexes of DNA topoisomerases
Subgroup Leader : Valerie LAMOUR
Teams : Regulation of DNA topology
Understand and cure myotubular/centronuclear myopathies
Subgroup Leader : Jocelyn LAPORTE
Teams : Pathophysiology of neuromuscular diseases
Pathophysiological role of vitamin D signalling
Subgroup Leader : Gilles LAVERNY
Teams : Pathophysiological role of nuclear receptor signalling
Drug discovery against nosocomial bacteria
Subgroup Leader : Nicolas LEVY
Teams : Regulation of DNA topology
Genotype/phenotype correlations in monogenic forms of ID/ASD (Genida)
Subgroup Leader : Jean-Louis MANDEL
Teams : Genetics and pathophysiology of neurodevelopmental Disorders
Human CCR4-NOT complex: regulation and effects on pathologies
Subgroup Leader : Fabienne MAUXION
Teams : Eukaryotic mRNA decay
Oncogenesis and progression of hormone-dependent cancers
Subgroup Leader : Daniel METZGER
Teams : Pathophysiological role of nuclear receptor signalling
Pathophysiological mechanisms involved in Fragile-X syndrome
Subgroup Leader : Hervé MOINE
Teams : Genetics and pathophysiology of neurodevelopmental Disorders
Development of high-throughput approaches for quantification of protein-ligand affinities
Subgroup Leader : Elodie MONSELLIER
Teams : Structural and Quantitative Interactomics
Genetic and molecular mechanisms involved in neurodevelopmental disorders
Subgroup Leader : Amelie PITON
Teams : Genetics and pathophysiology of neurodevelopmental Disorders
Function of the thyroid hormone nuclear receptor TRα1 in intestinal stem cell physiopathology
Subgroup Leader : Michelina PLATEROTI
Teams : Pathophysiological role of nuclear receptor signalling
Assemblies at the crossroad of DNA transcription and repair
Subgroup Leader : Arnaud POTERSZMAN
Teams : Transcription co-activators
Structure-function relationships of nuclear receptors and their co-regulators
Subgroup Leader : Natacha ROCHEL-GUIBERTEAU
Teams : Chemical biophysics of transcriptional signaling
Molecular mechanisms of chromatin reorganization
Subgroup Leader : Christophe ROMIER
Teams : Molecular Basis of Chromatin and Transcription Regulation
Vision and neurotransmission in ID and ASD models
Subgroup Leader : Michel ROUX
Teams : Pathophysiology of Down's syndrome and rare dose-effect diseases causing intellectual disabilities (ID) or autism spectrum disorders (ASD) and other comorbidities
Structure function of complexes involved in the HIV replication cycle, drug design
Subgroup Leader : Marc RUFF
Teams : Regulation of DNA topology
Factors and RNA modifications regulating mRNA decay
Subgroup Leader : Bertrand SERAPHIN
Teams : Eukaryotic mRNA decay
Translation/modification/RNA decay links
Subgroup Leader : Bertrand SERAPHIN
Teams : Eukaryotic mRNA decay
Numerical simulation studies of the structural dynamics of nuclear receptors
Subgroup Leader : Roland STOTE
Teams : Chemical biophysics of transcriptional signaling
Dynamics of chromatin structure and transcription regulation
Subgroup Leader : Laszlo TORA
Teams : Transcription complexes variability in development and disease
Nuclear Receptor Coregulators in Spermatogenesis
Subgroup Leader : Nadege VERNET
Teams : Pathophysiology of vitamin A signaling pathways